Donkeys belong to the Equidae family and as such are similar to equines in many ways. However, there are a number of significant features peculiar to the donkey that practitioners should be aware of when attempting to investigate and treat respiratory disease. These include differences in anatomy, physiology, pharmacokinetics, disease incidence and morbidity with certain infectious diseases. This chapter focuses on the differences as described in the published literature and recorded from cases at The Donkey Sanctuary in the UK.